Taurine is a conditionally essential amino acid that is the most abundant free amino acid in many tissues. Taurine is different than most other amino acids because it is not incorporated into proteins, but it does play many roles in the body, including bile acid conjugation, detoxification, membrane stabilization, osmoregulation, and modulation of excitatory neurotransmission and intracellular calcium levels. The mean taurine intake in humans is estimated to be around 60 mg daily, but supplementation can far exceed this amount and readily increases taurine levels in many tissues. This article will briefly cover some of the many possible utilities of taurine supplementation.
Exercise causes a significant reduction of taurine levels in skeletal muscle, as does aging [1-3]. In these conditions, supplemental taurine improves exercise performance and electrical and contractile properties of skeletal muscle in rodents, respectively [1, 3]. In healthy rats, taurine increased running time to exhaustion from 73.8 minutes to 98.8 minutes. Additionally, the weights of the gastrocnemius and soleus muscles were increased, but the difference was not statistically significant . A beverage containing taurine, caffeine, and simple carbs increases endurance performance in humans, and a significant portion of these effects is due to the taurine alone [1, 4]. However, it has not been established if it was due to a synergistic relationship, as taurine-only studies have not yet been conducted in humans. Taurine also counteracts exercise-induced weakness in a mouse model of dystrophy, and is superior to creatine in this regard , and it protects muscle tissue from ischemia-reperfusion injury . Among the postulated mechanisms of action are membrane stabilization and modulation of ion channels or calcium ion storage capacity [1, 3-4], although there could be a wide variety of reasons for this effect (such as osmoregulation).
The concentrations of taurine in the heart are very high, and it constitutes over 50% of the total free amino acid pool . Among the multiple roles it plays are protecting from excessive or inadequate intracellular calcium, acting as a membrane stabilizer, and protecting from injury and oxidative stress [7-8]. Although the taurine content in the heart is tightly regulated and not as subject to deprivation as many other tissues, chronic taurine depletion can result in severe cardiomyopathy
The brain is another area where taurine is particularly important. Taurine plays an essential role in both brain development and regeneration and promotes the survival and proliferation of neurons . Additionally, supplemental taurine exerts a definite pharmacological effect in the brain . Taurine is a potent neuroprotectant, protecting against glutamate excitotoxicity, cerebral ischemia, oxidative stress, and the buildup of toxins (including carbon tetrachloride and ammonia) [21-25]. Among other things, this neuroprotection is due to regulation of calcium homeostasis and apoptosis, direct scavenging of toxins, and a reduction of oxidative stress [23-26]. Taurine also holds promise as an anticonvulsant and in the prevention of epilepsy [7, 27-28].
The retina is another area where taurine is found in particularly high concentrations, although its role there is not well established. Visual dysfunction in both humans and animals has been linked with taurine deficiency that can be reversed with supplementation . Along with diltiazem and vitamin E, taurine helped reduce the progressive visual field reduction caused by retinitis pigmentosa, but as monotherapy results have not been clinically significant [7, 36]. Taurine also inhibits oxidative stress in cataractous lenses  and protects from retinal abnormalities due to diabetes in rat models, proving more effective on various levels than vitamin E and selenium [38-39].
Heavy metals & toxins
Taurine protects many of the body’s organs against toxicity and oxidative stress due to various substances. Taurine neutralizes the toxin hypochlorous acid, thus protecting from DNA damage . In the liver, taurine inhibits the toxic effects of high fructose feeding, alcohol, acetaminophen, and thioacetamide in rats; taurine also improves some markers in patients with hepatitis [7; 40-43]. In the kidneys, taurine protects against cisplatin toxicity and prevents renal damage from salt feeding in salt-sensitive rats [44-45]. Taurine also protects against ulcers caused by monochloramine, a toxin associated with H. pylori infection . Accumulation of heavy metals can have a variety of toxic effects, and taurine reduces the damage caused by excess levels cadmium, copper, and lead in rats [47-49]. Taurine also reduces the toxic effect of oxidized fish oil in rats .
In vitro, taurine improves recovery from burn injured skin, and a topical taurine gel accelerates wound healing in mice [51-52]. As an osmolyte, taurine helps maintain hydration in the epidermis when it is exposed to a dry environment , but the effect of oral taurine supplementation on skin hydration and healing has not been determined.
General health & life extension
Aging is associated with a decline in taurine content in various tissues, including liver, kidney, cerebellum, eye, spleen, blood, and skeletal muscle, and dietary supplementation with taurine can increase the taurine content to levels even above those of healthy adults [3, 54-55]. Taurine supplementation also reduces the elevated protein carbonyl levels associated with aging, aids in the restoration of protein and acid-soluble thiols in aged rats, blunts the age-related decline of IGF-1, and aids in the retention of antioxidant nutrients such as vitamin E and vitamin A [54-57].
Dosage & toxicity
Toxicity is not a concern with taurine, as no signs of toxicity have been indicated in animal studies . For general health and increased exercise performance, 1-4 g daily is commonly used (with at least 1 g prior to exercise), while most clinical trials for treatment of conditions have utilized dosages in the range of 3-6 g daily.
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